Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.

作者: Michaelyn C. Lux , Lisa C. Standke , Derek S. Tan

DOI: 10.1038/S41429-019-0171-2

关键词:

摘要: Adenylate-forming enzymes are a mechanistic superfamily that involved in diverse biochemical pathways. They catalyze ATP-dependent activation of carboxylic acid substrates as reactive acyl adenylate (acyl-AMP) intermediates and subsequent coupling to various nucleophiles generate ester, thioester, amide products. Inspired by natural products, sulfonyladenosines (acyl-AMS) mimic the tightly bound acyl-AMP reaction have been developed potent inhibitors adenylate-forming enzymes. This simple yet powerful inhibitor design platform has provided wide range biological probes well several therapeutic lead compounds. Herein, we provide an overview nine structural classes examples acyl-AMS for each.

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