Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings.

摘要: Clinical cytogenetic studies in horses have been ongoing for over half a century and clearly demonstrate that chromosomal disorders are among the most common non-infectious causes of decreased fertility, infertility, congenital defects. Large-scale surveys show almost 30% with reproductive or developmental problems chromosome aberrations, whereas abnormal karyotypes found only 2-5% general population. Among many abnormalities reported horse, unique rare. However, all agree there two recurrent conditions: X-monosomy SRY-negative XY male-to-female sex reversal, making up approximately 35% 11% abnormalities, respectively. The signature conditions horse rare absent other domestic species. progress equine genomics development molecular tools, qualitatively improved clinical cytogenetics today, allowing refined characterization aberrations understanding underlying mechanisms. While cutting-edge tools promise further improvements analysis, they will not entirely replace traditional cytogenetics, which still is straightforward, cost-effective, fastest approach initial evaluation potential breeding animals disorders.