Targeting monocyte chemoattractant protein-1 signalling in disease

作者: Janet Dawson , Wolfgang Miltz , Anis K Mir , Christoph Wiessner

DOI: 10.1517/14728222.7.1.35

关键词:

摘要: Monocyte chemoattractant protein-1 (MCP-1) has been implicated in many inflammatory and autoimmune diseases. The G-protein-coupled receptor CCR-2B is probably the most important MCP-1 vivo, loss of effector function alone sufficient to impair monocytic trafficking inflammation models. signalling appears be a relevant target, especially rheumatoid arthritis (RA). In RA patients, produced by synovial cells infiltrating monocytes, plasma concentrations correlate with swollen joint count, elevated serum were found juvenile patients active disease. Modulation experimental showed beneficial effects on destruction. With respect chronic neuroinflammation, critical role for established animal models multiple sclerosis. acute evidence detrimental stroke excitotoxic injury found. Several selective small molecular weight antagonists MCP-1-blocking antibodies have described. proof validity targeting disease, however, yet clinical trials.

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