Molecular and cellular mechanisms of macrophage survival in atherosclerosis

摘要: Macrophages play a key role in the initiation and progression of atherosclerotic plaques. Although significant number macrophages undergoes cell death during plaque development as result atherogenic stressors, advanced plaques are characterized by large macrophage content. Macrophage accumulation is mediated continuous recruitment monocytes, reduced emigration poor phagocytosis dead cells which may trigger secondary necrosis amplification inflammation. Moreover, an increasing body evidence indicates that have developed several strategies to survive proliferate adverse environment plaque. contain organic molecules or enzymes provide enhanced antioxidant protection. In addition, synthesis anti-apoptotic proteins upregulated cellular protection mechanisms such unfolded protein response autophagy activated promote survival. this review, we discuss these survival allow growth destabilization