Selection of coxsackievirus B4 variants with monoclonal antibodies results in attenuation
作者： B. S. Prabhakar , J. Srinivasappa , U. Ray
DOI: 10.1099/0022-1317-68-3-865
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摘要: Inoculation of suckling mice with coxsackievirus B4 (CB4) results in the death a majority animals. In this study we selected antigenic variants CB4 presence neutralizing monoclonal antibodies and tested them to see whether they were attenuated. Antigenic single antibody showed little or no attenuation by producing high mortality (60 100%). A double variant two considerable causing only 25% mortality. triple three was almost completely attenuated (killed 5% animals). Polypeptides from these for their ability interact used selection. These studies that resistance virus neutralization general due inability bind virus. However, one could but not neutralize virus, perhaps an alteration epitope. It is concluded selection using more than can lead
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