Histone Deacetylase Activity Regulates Chemical Diversity in Aspergillus

摘要: Bioactive small molecules are critical in Aspergillus species during their development and interaction with other organisms. Genes dedicated to production encoded clusters that can be located throughout the genome. We show deletion of hdaA, encoding an nidulans histone deacetylase (HDAC), causes transcriptional activation two telomere-proximal gene clusters—and subsequent increased levels corresponding (toxin antibiotic)—but not a telomere-distal cluster. Introduction additional HDAC mutant alleles ΔhdaA background had minimal effects on expression HdaA-regulated clusters. Treatment fungal genera inhibitors resulted overproduction several metabolites, suggesting conserved mechanism repression some secondary-metabolite Chromatin regulation small-molecule may enable filamentous fungi successfully exploit environmental resources by modifying chemical diversity.