5 Fungal Chromatin and Its Role in Regulation of Gene Expression

摘要: Changes in chromatin structure and composition are now recognized as important for gene regulation, especially the initiation of transcription, which access to transcriptional start sites genes is required. While there a rich literature centered on hemiascomycetous yeasts, less known about filamentous fungi, although they seem ideally suited comparative biology. This chapter summarizes current knowledge components, particular histones, reviews recent advances study histone modification enzymes fungi. Two major topics drive field forward fungi: formation maintenance constitutive heterochromatin studies modification-mediated regulation geared predominantly toward expression “cryptic” clusters that generate secondary metabolites. These present perhaps best example “facultative heterochromatin” Study these large regions promises fill existing gaps our chromatin-mediated undertaken by combination genomic, transcriptomic, metabolomic resources.