Effects of Palmitoyl CoA on Citrate and Malate Transport by Rat Liver Mitochondria

摘要: Abstract Palmitoyl CoA inhibited citrate transport from isolated rat liver mitochondria. Under conditions described, 50% inhibition was observed at about 6-8 nmol/mg of mitochondrial protein per ml. The percentage inversely proportional to the concentration counter-transporting anion in medium. Although comparable levels palmitoyl had little effect on malate exit dicarboxylate carrier, higher concentrations both and transport. The specificity by investigated examination effects tricarboxylate system fatty acids, CoASH, acetyl CoA, palmitoylcarnitine, deoxycholate, other molecules with surface active properties. None above compounds, sublytic concentrations, appreciably. low rapid could be prevented or partially reversed addition albumin.