Effect of diet on activity of enzymes involved in fatty acid and cholesterol synthesis.

摘要: Publisher Summary This chapter discusses the effect of diet on activity enzymes involved in fatty acid and cholesterol synthesis. Adipose tissue is major organ contributing to de novo synthesis nonlactating pig ruminant, while liver more important birds man. In rats mice, both organs contribute significantly species such as rat, where adipose synthesis, dietary manipulations generally affect tissues a similar fashion; however, there are exceptions. The quantity hepatic synthetase can regulate rate fed high-carbohydrate diets. Unlike change β -Hydroxy- -methylglutaryl-CoA reductase precedes changes acetate conversion cholesterol. Allosteric control enzyme plays role rapid regulation metabolic flux. Adaptive content reflect sustained flux adaptations longer term metabolism.