The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
作者： Ido Amit , Deborah R Winter , Steffen Jung
DOI: 10.1038/NI.3325
关键词:
摘要: Macrophages provide a critical systemic network cells of the innate immune system. Emerging data suggest that in addition, they have important tissue-specific functions that range from clearance of surfactant from the lungs to neuronal pruning and establishment of gut homeostasis. The differentiation and tissue-specific activation of macrophages require precise regulation of gene expression, a process governed by epigenetic mechanisms such as DNA methylation, histone modification and chromatin structure. We argue that epigenetic …
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