Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

摘要: Diabetic nephropathy is a major cause of chronic kidney disease and end-stage disease. However, so little known about alterations the glycopatterns in urine with development diabetic nephropathy. Presently, we interrogated specimens using lectin microarray. The results showed that expression levels Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency nephropathy; moreover, blotting indicated glycoproteins (90 kDa, 70 kDa, 40 kDa) may contribute to this alteration. Furthermore, STL difference between nondiabetic urinary protein microarray fabricated another 48 also potential indictor differentiate patients from Furtherly, 50 kDa were correlated In conclusion, our data provide pivotal information monitor distinguish renal based on precise proteins, but further studies are needed regard.