Microcirculation and diabetes.

摘要: Abstract Many late complications of diabetes stem from damage to the microcirculation. Changes in microvascular wall, haemodynamic control and circulating blood may all contribute impairment capillary transfer function although relative importance various possible mechanisms is unclear. Early functional disturbance appears more responsive optimal diabetic than established disease, as microangiopathy becomes clinically apparent organ tissue compounded by secondary mechanisms. Until learnt biochemical cellular basis component pathogenetic early disease remains sole available primary prevention strategy, evidence emerging that manipulation haemodynamics have therapeutic potential.