An overview of anticoagulant therapy for coronary artery disease

摘要: Abstract From animal experiments it appears that anticoagulant therapy can indeed be antithrombotic, both with regard to venous and arterial occlusion. Anticoagulant has proved valuable in human thrombotic disease, but its value disease is still doubt. Even those studies of the effect upon acute myocardial infarction which have not demonstrated any advantage mortality rates frequently confirmed simultaneously antithrombotic effectiveness such treatment. The inference seems other aspects this treatment (antishock measures, better fluid electrolyte balance, etc.) are more important life death than reduced thromboembolism. level hypocoagulability comparable required for antithrombosis may incompatible long-term ambulatory therapy. This known certain at present. Bjerkelund's British Medical Research Council would seem indicate some transient protection persons—possibly only men—under sixty years age. uncertainty exists because present methods most widely used control almost certainly measure neither events responsible nor induced coagulation defect causing hemorrhage. Instead, they an associated phenomenon imperfectly indirectly reflect we should like measure. One conclusion drawn Not objective short- or as regimen morally justifiable, indispensable. Additionally, siliconized tube clotting time degree platelet adhesiveness prove accurate reflections wish currently prothrombin time. An imaginative clinically applicable technic measurement hemorrhagic risk follow when further experimental clarify our knowledge fundamental nature mechanism thrombosis. A utilization drugs then possible will afford effective prophylaxis against More more, technics, wisest respect reluctance Rytand [18], Evans [1], Russek Zohman [26], McMichael Parry [52], Honey Truelove [48], others [134–136] accept unqualified choice coronary artery disease.