Magnetic resonance relaxivity of dendrimer-linked nitroxides.
作者： Carl S. Winalski , Sonya Shortkroff , Robert V. Mulkern , Erika Schneider , Gerald M. Rosen
DOI: 10.1002/MRM.10312
关键词:
摘要: The relaxivity and bioreduction rates of eight dendrimer-linked nitroxides varying in the number per molecule were measured potential use these compounds as MR contrast agents was demonstrated. T1 T2 relaxivities, at room temperature 1.5 T, varied linearly with for up to 16 molecule. Fourth-generation polypropylenimide- (DAB) third-generation polyamidoamine- (PAMAM) found have greater than gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). dendrimer increased over that a single nitroxide, allowing decreased dose achieve differential evaluations. Rates nitroxide below detection threshold using EPR spectroscopy generation 2 dendrimers higher. A pilot assessment vivo cartilage uptake compared intraarticular injection three structurally different Gd-DTPA saline demonstrated high affinity DAB-dendrimer-linked normal rabbit articular cartilage. From results, it is evident target-specific can be designed. Magn Reson Med 48:965–972, 2002. © 2002 Wiley-Liss, Inc.
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