Forkhead Box(O) in Control of Reactive Oxygen Species and Genomic Stability to Ensure Healthy Lifespan
作者： Paraskevi Charitou , Boudewijn M.T. Burgering
关键词:
摘要: Abstract Significance: Transcription factors of the Forkhead box O class (FOXOs) are associated with lifespan and play a role in age-related diseases. FOXOs, therefore, serve as paradigm for developing an understanding to how diseases, such cancer diabetes interconnect lifespan. Understanding regulatory inputs on FOXO may reveal changes these signaling pathways affect disease Recent Advances: Numerous regulators have now been described clear evolutionary conserved has emerged phosphoinositide-3 kinase/protein kinase B (also known c-Akt or AKT) c-jun N-terminal signaling. Analysis function context shown importance FOXO-mediated transcriptional regulation cell cycle progression other fates, metabolism, stress resistance, apoptosis mediating Critical Issues: Persistent DNA damage is also ...
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