Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

作者: Diego H Castrillon , Lili Miao , Ramya Kollipara , James W Horner , Ronald A DePinho

DOI: 10.1126/SCIENCE.1086336

关键词: BiologyFOXO FamilyFollicular phaseOvaryFollicular atresiaEndocrinologyOvarian follicleInternal medicinePremature ovarian failureOvulationPremature agingCell biology

摘要: Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a–/–female …

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