Ocular adverse effects associated with systemic medications : recognition and management.

摘要: This article reviews several retrospective case series and reported adverse events regarding common ocular effects related to systemic therapy. It is not intended as a comprehensive summary of these well described drug reactions, nor it cover the complete spectrum all Many drugs may produce toxicity, including bisphosphonates, topiramate, vigabatrin, isotretinoin other retinoids, amiodarone, ethambutol, chloroquine hydroxychloroquine, tamoxifen, quetiapine, cyclo-oxygenase (COX)-2 inhibitors, erectile dysfunction agents some herbal medications. For this review, certainty effect profile each medication was evaluated according WHO Causality Assessment Guide. A certain relationship has been established for pamidronate alendronate causes scleritis, uveitis, conjunctivitis blurred vision. Topiramate adversely causing symptoms consistent with acute angle-closure glaucoma, typically bilateral. Vigabatrin shown cause bilateral irreversible visual field defects attributed underlying medication-induced retinal pathology. Isotretinoin should be considered in differential diagnosis any patient pseudotumour cerebri. Patients taking amiodarone hydroxychloroquine monitored screened regularly development optic neuropathy maculopathy, respectively. Sildenafil changes perception possible, yet certain, anterior ischaemic neuropathy. tamoxifen also dose-dependent maculopathy decreased colour COX-2 inhibitors included reversible conjunctivitis. Several medications canthaxanthine, chamomile, datura, Echinacea purpurea, Ginkgo biloba liquorice have associated effects. role healthcare professionals detect, treat educate public about reactions they are an important health problem.