Granulomatous Amebic Encephalitis in a Patient with AIDS: Isolation of Acanthamoeba sp. Group II from Brain Tissue and Successful Treatment with Sulfadiazine and Fluconazole

摘要: A patient with AIDS, treated highly active antiretroviral therapy and trimethoprim-sulfamethoxazole, presented confusion, a hemifield defect, mass lesion in the right occipital lobe. brain biopsy confirmed granulomatous amebic encephalitis (GAE) due to Acanthamoeba castellanii. The was fluconazole sulfadiazine, surgically excised. This is first case of AIDS-associated GAE responding favorably therapy. existence solitary lesion, absence other sites infection, intense cellular response spite very low CD4 count conditioned favorable outcome. We review discuss diagnostic microbiologic options for laboratory diagnosis infections free-living amebae.