Solid lipid nanoparticles as a drug delivery system to across the blood-brain barrier.

摘要: Abstract Solid lipid nanoparticles (SLNs) were prepared by biocompatible and biodegradable solid-phase lipids. β-elemene is a safe natural essential oil with broad-spectrum anti-tumor activity. However, its clinical application has been adversely affected poor water solubility limited bioavailability. SLN incorporation potential strategy to bypass the blood-brain barrier, most important factor limiting bioactivity of neurotherapeutics. The SLNs-β same efficacy as commercially available elemene in vitro an enhanced brain drug accumulation in vivo. survival rate data was promising acute toxicity experiment proved safety. All these suggested that SLN-β effective delivery system, especially for tumor therapy, warrants further development.