Relationship between β-defensin-1 gene polymorphism and susceptibility and prognosis of acute respiratory distress syndrome

摘要: OBJECTIVE The 1st exon 5' noncoding region rs1799946 (-52A/G), rs1800972 (-44C/G), rs11362 (-20A/G) 3 single-nucleotide polymorphisms (SNPs) on human β-defensin-1 (HBD-1) gene affect its transcription and posttranscriptional mRNA stability then the activity of HBD-1. This study was to investigate effects HBD-1 rs1799946, rs1800972, locus SNPs genetic susceptibility prognosis acute respiratory distress syndrome (ARDS). METHODS A total 300 patients with ARDS (ARDS group) 240 who were admitted intensive care unit had a high risk but did not progress (control included in this study. genotypes serum detected. Patients followed for 60 days development as primary outcome, ARDS-related mortality organ dysfunction secondary outcomes. RESULTS mutations factors (P > .05). Mutation allele G factor ARDS. There no significant difference levels between different wild type, heterozygous, mutant homozygous gradually decreased, statistically (P < .001). 60-day survival rate subjects homozygote at decreased sequentially (81.7%, 48.9%, 39.7%), (P < .05). CONCLUSION SNP (-44C/G) is associated carriers are more likely develop have poor prognosis.