A novel cDNA encodes a putative hRALY-like protein, hRALYL.
作者： Chao-neng Ji , Jin-Zhong Chen , Yi Xie , Shu Wang , Ji Qian
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摘要: High throughput cDNA sequencing and 5′-rapid amplification of ends (5′RACE) isolated two cDNAs that shared the same open reading fragment (ORF). Northern blot analysis with fetal brain mRNA blots detected transcripts length 3.2 kb 2.2 respectively. The ORF encodes a 291 residues putative protein shares great homology hRALY hnRNPC. So it was named like protein, hRALYL. Expression pattern by multiple-issue (MTC) panel based RT-PCR. It revealed hRALYL were expressed ubiquitously in human tissues different intensities. transcript is highest brain. Blast found corresponding to contig NT_008292, which gene containing at least 9 exons located on chromosome 8q21.13-8q21.2. might be member hnRNPC subfamily.
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G L Wolff, Body weight and cancer. The American Journal of Clinical Nutrition. ,vol. 45, pp. 168- 180 ,(1987) , 10.1093/AJCN/45.1.168
M. Görlach, M. Wittekind, R.A. Beckman, L. Mueller, G. Dreyfuss, Interaction of the RNA-binding domain of the hnRNP C proteins with RNA. The EMBO Journal. ,vol. 11, pp. 3289- 3295 ,(1992) , 10.1002/J.1460-2075.1992.TB05407.X
W M LeStourgeon, L Shahied-Milam, S R Soltaninassab, J G McAfee, A major determinant of hnRNP C protein binding to RNA is a novel bZIP-like RNA binding domain. RNA. ,vol. 2, pp. 1139- 1152 ,(1996)
G. S. Barsh, H. Vrieling, P. J. Saxon, C. J. Epstein, M. W. Miller, D. M. J. Duhl, M. E. Stevens, Pleiotropic effects of the mouse lethal yellow (Ay) mutation explained by deletion of a maternally expressed gene and the simultaneous production of agouti fusion RNAs. Development. ,vol. 120, pp. 1695- 1708 ,(1994) , 10.1242/DEV.120.6.1695
C. Burd, G Dreyfuss, Conserved structures and diversity of functions of RNA-binding proteins. Science. ,vol. 265, pp. 615- 621 ,(1994) , 10.1126/SCIENCE.8036511
Weiping Jiang, Xiaoxuan Guo, Veer P Bhavanandan, Four distinct regions in the auxiliary domain of heterogeneous nuclear ribonucleoprotein C-related proteins Biochimica et Biophysica Acta. ,vol. 1399, pp. 229- 233 ,(1998) , 10.1016/S0167-4781(98)00114-6
Hidenobu Kawamura, Yusuke Tomozoe, Tadayuki Akagi, Daisuke Kamei, Michiru Ochiai, Michiyuki Yamada, Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. Journal of Biological Chemistry. ,vol. 277, pp. 2732- 2739 ,(2002) , 10.1074/JBC.M108477200
Giuseppe Biamonti, Silvano Riva, New insights into the auxiliary domains of eukaryotic RNA binding proteins FEBS Letters. ,vol. 340, pp. 1- 8 ,(1994) , 10.1016/0014-5793(94)80162-2
Irina Khrebtukova, Alexander Kuklin, Richard P Woychik, Edward J Michaud, ALTERNATIVE PROCESSING OF THE HUMAN AND MOUSE RALY GENES Biochimica et Biophysica Acta. ,vol. 1447, pp. 107- 112 ,(1999) , 10.1016/S0167-4781(99)00126-8
N. J. Proudfoot, G. G. Brownlee, 3′ Non-coding region sequences in eukaryotic messenger RNA Nature. ,vol. 263, pp. 211- 214 ,(1976) , 10.1038/263211A0