Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.
作者： A. Delprato , B. Bonheur , M.-P. Algéo , P. Rosay , L. Lu
DOI: 10.1111/GBB.12259
关键词:
摘要: Variation in hippocampal neuroanatomy correlates well with spatial learning ability mice. Here, we have studied both and behavior 53 isogenic BXD recombinant strains derived from C57BL/6J DBA/2J parents. A combination of experimental, neuroinformatic systems genetics methods was used to test the genetic bases variation covariation among traits. Data were collected on seven subregions CA3 CA4 after testing memory an eight-arm radial maze task. Quantitative trait loci identified for structure, including areas intra- infrapyramidal mossy fibers (IIPMFs), stratum radiatum pyramidale, a parameter, error rate. We multiple gene variants linked either structural differences or behavior. Gpc4 Tenm2 are strong candidate genes that may modulate IIPMF areas. Analysis expression networks correlations highlight several processes influencing morphometrical learning.
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