Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis
作者： Sorayya Kheirouri , Vahid Hadi , Mohammad Alizadeh
DOI: 10.3109/08820139.2016.1153649
关键词:
摘要: ABSTRACTBackground and objectives: Abundant evidence indicates the involvement of CD4+, CD8+, CD4+CD25+ T lymphocytes in induction and/or protection rheumatoid arthritis (RA). We aimed to investigate modulatory effect Nigella sativa (NS) oil on selected cell subset percentage females with RA.Methods: A randomized, double-blinded placebo-controlled, 2 months, parallel-group clinical trial was conducted. Forty-three female patients (20–50 years) mild moderate RA were recruited assigned into NS (n = 23) placebo 20) groups receive one gram oil, or starch, capsule two divided doses, respectively. The disease activity scores 28 joints (DAS28) calculated percentages cells examined using flow cytometry.Results: Treatment led significant reduction serum high-sensitivity C-reactive protein (hs-CRP) level DAS-28 score an improved number swollen compared baseline pla...
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