Tolerogenic function of Blimp-1 in dendritic cells

摘要: Blimp-1 has been identified as a key regulator of plasma cell differentiation in B cells and effector/memory function T cells. We demonstrate that dendritic (DCs) is required to maintain immune tolerance female but not male mice. Female mice lacking expression DCs (DCBlimp-1ko) or haploid for exhibit normal DC development an altered develop lupus-like autoantibodies. Although have implicated the pathogenesis lupus, defect previously shown initiate disease process. Blimp-1ko display increased production IL-6 preferentially induce follicular helper (TFH cells) vitro. In vivo, expansion TFH associated with enhanced germinal center (GC) response autoreactivity. These studies critical role tolerogenic show diminished can result aberrant activation adaptive system serology gender-specific manner. This study particular interest because polymorphism associates SLE.