Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases

摘要: Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) macrophages, two belonging innate system. The protein acts a direct indirect regulator target genes by recruiting chromatin modification factors regulating microRNA expression, respectively. In DCs, one components involved antigen presentation. Genome-wide association polymorphisms associated with multiple autoimmune diseases system lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease PRDM1, gene encoding protein. this review, we will discuss regulatory DCs main focus on tolerogenic mechanisms required protect against development diseases.