Fat Composition Changes in Bone Marrow During Chemotherapy and Radiation Therapy

摘要: Purpose To quantify changes in bone marrow fat fraction and determine associations with peripheral blood cell counts. Methods Materials In this prospective study, 19 patients received either highly myelotoxic treatment (radiation therapy plus cisplatin, 5-fluorouracil mitomycin C [FU/MMC], or cisplatin/5-FU/cetuximab) less myelotoxic (capecitabine-radiation no concurrent chemotherapy). Patients underwent MR imaging venipuncture at baseline, midtreatment, posttreatment visits. We performed mixed effects modeling of the mean proton density (PDFF[%]) by linear time, treatment, vertebral column region (lumbar [L]4-sacral [S]2 vs thoracic [T]10-L3 cervical[C]3-T9), while controlling for cumulative dose other confounders. Spearman rank correlations were white (WBC) counts versus differences PDFF(%) before after treatment. Results Cumulative was associated a 0.43% per Gy ( P =.004) increase PDFF(%). highly group, we observed significant visit within L4-S2 (10.1%, =.01), relative to reference C3-T9. did not observe according region. Within L4-S2, difference between groups change (5.36%, =.04). Rank inverse log WBC overall T10-S2 ranged from 0.69 0.78 Conclusions Magnetic resonance quantification is sensitive composition that result chemoradiation therapy. These are This study supports rationale marrow-sparing planning reduce risk hematologic toxicity.