Late-onset minor and major depression: early evidence for common neuroanatomical substrates detected by using MRI

摘要: The purpose of our study was to examine the neuroanatomical correlates late-onset minor and major depression compare them with similar measures obtained from nondepressed controls. Our groups were comprised 18 patients depression, 35 diagnosed 30 All subjects scanned by using a 1.5-tesla MRI scanner. Absolute whole brain volume normalized prefrontal temporal lobe volumes used for comparison among groups. findings indicate that present specific abnormalities are comparable group but significantly different Normalized show significant linear trend severity decreasing illness severity. Whole did not differ These have broad implications biology late-life suggest there may be common neurobiological substrates underlie all clinically forms mood disturbances.