Levels of Solid State Properties: Role of Different Levels During Pharmaceutical Product Development

摘要: Abstract Oral and liquid solids are the most widely popularly used therapeutic goods which provide ease of administration cost-effective solutions for other dosage forms. Development tablets capsules (primary orals solids) existing drugs or a new chemical entity requires an in-depth understanding their solid-state properties. Structural features (1°/2°/3°/4°), structural conformation, solid state (amorphous, solvates, hydrates, crystalline), stability (chemical physical), general characteristics such as particles size some major Many procedures methodologies involved in pharmaceutical product development (salt formation, granulation, mixing, blending, homogenization, etc.) require complete knowledge From perspective, states bulk drug (polymorphs, enantiomer, crystal) determine apparent solubility turn govern systemic availability that drug. This chapter also aims to discuss concepts polymorph types, formulation, evaluation along with different levels properties, molecular level, particle level. We end providing brief overview on importance significance properties development.