Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them

摘要: Abstract Drug resistance can occur at the individual cellular level or as a result of properties tumor microenvironment. The convoluted vasculature within tumors results in robustly proliferating well-nourished cells located proximal to functional blood vessels and regions slowly (often hypoxic) distal vessels. Irregular flow large distances between solid lead poor drug distribution them such that from are exposed ineffective concentrations drug, resulting therapeutic resistance. Strategies improve complement anticancer drugs hold promise for increasing antitumor effects without corresponding increases normal tissue toxicity. In particular, use hypoxia-targeted agents modulation autophagy have shown promising enhancing activity hence efficacy. this review, we describe causes chemotherapy relate microenvironment potential by countering mechanisms