Sildenafil does not improve steady state cardiovascular hemodynamics, peak power, or 15-km time trial cycling performance at simulated moderate or high altitudes in men and women

摘要: Sildenafil improves oxygen delivery and maximal exercise capacity at very high altitudes (≥4,350 m), but it is unknown whether sildenafil these variables longer-duration performance moderate where competitions are more common. The purpose of this study was to determine the effects on cardiovascular hemodynamics, arterial saturation (SaO2), peak (W peak), 15-km time trial in endurance-trained subjects simulated (MA; ~2,100 m, 16.2% FIO2) (HA; ~3,900 m, 12.8% altitudes. Eleven men ten women completed two HA W trials after ingesting placebo or 50 mg sildenafil. Subjects then four (30 min 55% altitude-specific peak + 15-km trial) MA All were performed randomized, counterbalanced, double-blind fashion. had little influence hemodynamics HA, did result higher SaO2 values (+3%, p < 0.05) compared during steady state HA. 19% lower than SL (p < 0.001) not significantly affected by Similarly, slower (28.1 ± 0.5 min, p = 0.016) (30.3 ± 0.6 min, p < 0.001) (27.5 ± 0.6 min) unaffected We conclude that unlikely exert beneficial <4,000 m for a majority population.