JOINT ACTION OF CLOMIPHENE CITRATE AND HUMAN PITUITARY GONADOTROPHINS

作者: A.C. Crooke , MehrooD. Hansotia , P.V. Bertrand

DOI: 10.1016/S0140-6736(69)91529-3

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摘要: Abstract During the course of sensitivity tests eighteen patients were treated at different times with same dosages follicle-stimulating hormone (F.S.H.) and human chorionic gonadotrophin (H.C.G.) without clomiphene citrate. Nine out fifteen who provided sufficient data for analysis given F.S.H. which on average 40% minimum effective dose. None responded to this treatment (as judged by œstriol pregnanediol excretion). Six others 72% dose All combined gonadotrophins citrate but only three respond alone. In these six cases augmented activity a factor 173% (95% fiducial limits 101-788%).

参考文章(6)
Sir Ronald Aylmer Fisher, Statistical Methods for Research Workers ,(1925)
R. F. Palmer, A SHORT METHOD FOR THE ESTIMATION OF OESTRIOL IN URINE* BJOG: An International Journal of Obstetrics and Gynaecology. ,vol. 71, pp. 744- 748 ,(1964) , 10.1111/J.1471-0528.1964.TB04351.X
E. RABAU, S. MASHIACH, D. M. SERR, H. MELMED, Induction of ovulation by combined administration of human menopausal gonadotropins and clomiphene citrate. Obstetrics & Gynecology. ,vol. 31, pp. 110- 115 ,(1968) , 10.1097/00006250-196801000-00018
A. KLOPPER, EILEEN A. MICHIE, J. B. BROWN, A method for the determination of urinary pregnanediol. Journal of Endocrinology. ,vol. 12, pp. 209- 219 ,(1955) , 10.1677/JOE.0.0120209
WR BUTT, AC CROOKE, FJ CUNNINGHAM, Studies on human urinary and pituitary gonadotrophins. Biochemical Journal. ,vol. 81, pp. 596- 605 ,(1961) , 10.1042/BJ0810596
L.W. Cox, R.I. Cox, T.L. Black, Induction of ovulation. An attempt to avoid complications. American Journal of Obstetrics and Gynecology. ,vol. 102, pp. 177- 185 ,(1968) , 10.1016/0002-9378(68)90316-5