Epigenetic mechanisms involved in developmental nutritional programming.

摘要: The ways in which epigenetic modifications fix the effects of early environmental events, ensuring sustained responses to transient stimuli, result modified gene expression patterns and phenotypes later life, is a topic considerable interest. This review focuses on recently discovered mechanisms calls into question prevailing views about dynamics, position functions marks. Most studies have addressed long-term small number marks, at global or individual level, stressors humans animal models. In parallel, increasing numbers based high-throughput technologies focusing mice revealed additional complexity processes, by highlighting importance crosstalk between different A developmental origin health disease metabolic programming identified links nutrition, processes illness. existence self-propagating cycle has been demonstrated. Moreover, recent demonstrate an obvious sexual dimorphism both for trajectories response same insult. Despite progress, we are still far from understanding how, when where disturb key mechanisms. Thus, identifying original marks their changes throughout development during individual’s lifetime over several generations remains challenging issue.