Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome.
作者： Kerstin Melchior , Joachim W. Dudenhausen , Andreas Plagemann , Thomas Harder , Matthias Brunn
DOI: 10.1113/JPHYSIOL.2009.176156
关键词:
摘要: Pre‐ and neonatal overfeeding programmes a permanent obesity disposition and accompanying diabetic and cardiovascular disorders, by unknown mechanisms. We proposed that …
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jphysiol.org参考文章(63)
B Liu, M Mortrud, M J Low, DNA elements with AT-rich core sequences direct pituitary cell-specific expression of the pro-opiomelanocortin gene in transgenic mice. Biochemical Journal. ,vol. 312, pp. 827- 832 ,(1995) , 10.1042/BJ3120827
J. Drouin, Y.L. Sun, M. Chamberland, Y. Gauthier, A. De Léan, M. Nemer, T.J. Schmidt, Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. The EMBO Journal. ,vol. 12, pp. 145- 156 ,(1993) , 10.1002/J.1460-2075.1993.TB05640.X
C D Minth, J E Dixon, Expression of the human neuropeptide Y gene. Journal of Biological Chemistry. ,vol. 265, pp. 12933- 12939 ,(1990) , 10.1016/S0021-9258(19)38249-3
C.A. Minth-Worby, Transcriptional regulation of the human neuropeptide Y gene by nerve growth factor. Journal of Biological Chemistry. ,vol. 269, pp. 15460- 15468 ,(1994) , 10.1016/S0021-9258(17)40701-0
Michael W. Schwartz, Stephen C. Woods, Daniel Porte, Randy J. Seeley, Denis G. Baskin, Central nervous system control of food intake Nature. ,vol. 404, pp. 661- 671 ,(2000) , 10.1038/35007534
Sonja Fahrenkrog, Thomas Harder, Elke Stolaczyk, Kerstin Melchior, Kerstin Franke, Joachim W. Dudenhausen, Andreas Plagemann, Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism. Journal of Nutrition. ,vol. 134, pp. 648- 654 ,(2004) , 10.1093/JN/134.3.648
Plagemann, Harder, Rake, Waas, Melchior, Ziska, Rohde, Dörner, Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. Journal of Neuroendocrinology. ,vol. 11, pp. 541- 546 ,(1999) , 10.1046/J.1365-2826.1999.00357.X
Helga Davidowa, Andreas Plagemann, Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats. Neuroreport. ,vol. 18, pp. 521- 524 ,(2007) , 10.1097/WNR.0B013E32805DFB93
Xiaolei Pan, Solomon S. Solomon, Dawn M. Borromeo, Antonio Martinez-Hernandez, Rajendra Raghow, Insulin deprivation leads to deficiency of Sp1 transcription factor in H-411E hepatoma cells and in streptozotocin-induced diabetic ketoacidosis in the rat. Endocrinology. ,vol. 142, pp. 1635- 1642 ,(2001) , 10.1210/ENDO.142.4.8083
Helga Davidowa, Andreas Plagemann, Decreased inhibition by leptin of hypothalamic arcuate neurons in neonatally overfed young rats. Neuroreport. ,vol. 11, pp. 2795- 2798 ,(2000) , 10.1097/00001756-200008210-00037