Comparison of postoperative pain in the first and second knee in staged bilateral total knee arthroplasty: Clinical evidence of enhanced pain sensitivity after surgical injury

作者: Mi-Hyun Kim , Francis Sahngun Nahm , Tae Kyun Kim , Moon Jong Chang , Sang-Hwan Do

DOI: 10.1016/J.PAIN.2013.08.027

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摘要: Abstract Staged bilateral total knee arthroplasty (TKA) may provide an ideal clinical model for the study of central sensitization. In staged TKA, hyperalgesia be induced as a result repeated surgical injury possibly via sensitization, which can decrease functional outcomes. Therefore, we hypothesized that in patients would have greater pain second operated than first. Thirty undergoing TKA at 1-week interval were enrolled. Postoperative pain, was reported on basis visual analog scale (VAS; primary outcome) rest and maximum flexion, amount patient-controlled analgesic (i.v. fentanyl) rescue ketoprofen; secondary outcomes) administered during 48 h after operation, compared between first TKA. VAS scores flexion ( P

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