Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.

摘要: To clarify the mechanisms by which angiotensin-converting enzyme (ACE) inhibitors lower blood pressure or inhibit cardiac hypertrophy, we analyzed correlations among tissue ACE activities, and hypertrophy. In spontaneously hypertensive rats (SHR), pressure, heart weight activities in plasma various tissues were measured 3, 24 48 h after repeated daily treatment for 2 weeks with trandolapril, perindopril, temocapril enalapril. For all four inhibitors, plasma, aorta kidney significantly reduced 3 last treatment. Although hypotensive effects maintained at h, not suppressed Even enalapril could suppress activity brain, heart. Significant between observed while brain correlated changes pressure. decreases ratio of to body SHR treated trandolapril whereas they The was vascular may be important targets terms ability respectively.