Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats.
作者： Kazuyoshi KIRIMURA , Shinji TAKAI , Denan JIN , Michiko MURAMATSU , Kanta KISHI
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摘要: Vascular smooth muscle cells in spontaneously hypertensive rats (SHR) express angiotensin II-forming chymase (rat vascular [RVCH]), which may contribute to blood pressure regulation. In this study, we studied whether chymase-dependent II formation contributes the regulation of SHR. The systolic 16-week-old Wistar-Kyoto (WKY) was 113±9 mmHg, compared 172±3 mmHg Using synthetic substrates for measuring angiotensin-converting enzyme (ACE) and activities, it found that both ACE activities extracts from SHR aortas were significantly higher than those WKY rat aortas. I as a substrate, be rats, its completely suppressed by an inhibitor, but not inhibitor. RVCH mRNA expression could detected aorta either or carotid arteries isolated SHR, I-induced vasoconstriction Angiotensin pressor responses also inhibited they affected inhibitor receptor blocker showed equipotent hypotensive effects, did have effect. These results indicated regulate present study. (Hypertens Res 2005; 28: 457‐464)
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sci-hub.se 参考文章(33)
T. Vartio, H. Seppä, A. Vaheri, Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G. Journal of Biological Chemistry. ,vol. 256, pp. 471- 477 ,(1981) , 10.1016/S0021-9258(19)70161-6
H Urata, A Kinoshita, K S Misono, F M Bumpus, A Husain, Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. Journal of Biological Chemistry. ,vol. 265, pp. 22348- 22357 ,(1990) , 10.1016/S0021-9258(18)45712-2
P.N. Benfey, F.H. Yin, P. Leder, Cloning of the mast cell protease, RMCP II. Evidence for cell-specific expression and a multi-gene family. Journal of Biological Chemistry. ,vol. 262, pp. 5377- 5384 ,(1987) , 10.1016/S0021-9258(18)61198-6
J. Cohen, Investigators detail HIV's fatal handshake. Science. ,vol. 274, pp. 502- 502 ,(1996) , 10.1126/SCIENCE.274.5287.502
H Ide, H Itoh, M Tomita, Y Murakumo, T Kobayashi, H Maruyama, Y Osada, Y Nawa, Cloning of the cDNA encoding a novel rat mast-cell proteinase, rMCP-3, and its expression in comparison with other rat mast-cell proteinases. Biochemical Journal. ,vol. 311, pp. 675- 680 ,(1995) , 10.1042/BJ3110675
Shinji TAKAI, Denan JIN, Masato SAKAGUCHI, Mizuo MIYAZAKI, Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertension Research. ,vol. 27, pp. 213- 219 ,(2004) , 10.1291/HYPRES.27.213
Takafumi KOGA, Hidenori URATA, Yukiko INOUE, Takafumi HOSHINO, Takehiro OKAMOTO, Akira MATSUNAGA, Misao SUZUKI, Junichi MIYAZAKI, Munehito IDEISHI, Kikuo ARAKAWA, Keijiro SAKU, Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy. Hypertension Research. ,vol. 26, pp. 759- 768 ,(2003) , 10.1291/HYPRES.26.759
Shinji Takai, Denan Jin, Masayoshi Nishimoto, Atsushi Yuda, Masato Sakaguchi, Keiichi Kamoshita, Koichi Ishida, Yoshikazu Sukenaga, Shinjiro Sasaki, Mizuo Miyazaki, Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein Life Sciences. ,vol. 69, pp. 1725- 1732 ,(2001) , 10.1016/S0024-3205(01)01255-3
U. M. Chandrasekharan, S. Sanker, M. J. Glynias, S. S. Karnik, A. Husain, Angiotensin II-Forming Activity in a Reconstructed Ancestral Chymase Science. ,vol. 271, pp. 502- 505 ,(1996) , 10.1126/SCIENCE.271.5248.502
H. Ju, R. Gros, X. You, S. Tsang, M. Husain, M. Rabinovitch, Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 7469- 7474 ,(2001) , 10.1073/PNAS.131147598