L-2-amino-4-methoxy-cis-but-3-enoic acid, a potent inhibitor of the enzymatic synthesis of S-adenosylmethionine
作者： Janice R. Sufrin , J.B. Lombardini , Dennis D. Keith
DOI: 10.1016/0006-291X(82)91102-0
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摘要: Abstract L -2- Amino -4- methoxy - cis but -3- enoic acid was synthesized and found to be an extremely potent inhibitor of ATP: L-methionine adenosyltransferase isozymes rat liver Novikoff solid hepatoma. The inhibitory potency amino significantly higher than that its structural analogues, L-methoxinine trans . Ki values the Km are comparable for tumor isozymes, suggesting a close correlation between enzyme-bound conformations these two molecules.
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sci-hub.se 参考文章(11)
Michel CABOCHE, Jean-Pierre BACHELLERIE, RNA Methylation and Control of Eukaryotic RNA Biosynthesis FEBS Journal. ,vol. 74, pp. 19- 29 ,(1977) , 10.1111/J.1432-1033.1977.TB11362.X
Gary L. Kunz, Jerald L. Hoffman, Ching-Shu Chia, Beth Stremel, Separation of rat liver methionine adenosyltransferase isozymes by hydrophobic chromatography Archives of Biochemistry and Biophysics. ,vol. 202, pp. 565- 572 ,(1980) , 10.1016/0003-9861(80)90463-4
Kenneth Dimock, C. Martin Stoltzfus, Cycloleucine blocks 5'-terminal and internal methylations of avian sarcoma virus genome RNA. Biochemistry. ,vol. 17, pp. 3627- 3632 ,(1978) , 10.1021/BI00610A032
Michael J. Tisdale, The effect of the methionine antagonist L-2-amino-4-methoxy-trans-3-butenoic acid on the growth and metabolism of Walker carcinosarcoma in vitro. Biochemical Pharmacology. ,vol. 29, pp. 501- 508 ,(1980) , 10.1016/0006-2952(80)90369-X
Paul Talalay, A. W. Coulter, J. B. Lombardini, Structural and conformational analogues of L methionine as inhibitors of the enzymatic synthesis of S adenosyl L methionine. I. Saturated and unsaturated aliphatic amino acids Molecular Pharmacology. ,vol. 10, pp. 293- 304 ,(1974)
JAMES P. SCANNELL, DAVID L. PRUESS, THOMAS C. DEMNY, LILIAN H. SELLO, THOMAS WILLIAMS, ARTHUR STEMPEL, ANTIMETABOLITES PRODUCED BY MICROORGANISMS. V1) L-2-AMINO-4-METHOXY-TRANS-3-BUTENOIC ACID The Journal of Antibiotics. ,vol. 25, pp. 122- 127 ,(1972) , 10.7164/ANTIBIOTICS.25.122
Janice R. Sufrin, A. W. Coulter, Paul Talalay, Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acids. Molecular Pharmacology. ,vol. 15, pp. 661- 677 ,(1979)
Paul Talalay, A. W. Coulter, J. B. Lombardini, Structural and Conformational Analogues of L-Methionine as Inhibitors of the Enzymatic Synthesis of S-Adenosyl-L-Methionine : II. Aromatic Amino Acids Molecular Pharmacology. ,vol. 10, pp. 305- 314 ,(1974)
Paul Talalay, A. W. Coulter, J. B. Lombardini, Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine. Molecular Pharmacology. ,vol. 6, pp. 481- 499 ,(1970)
Paul Talalay, A. W. Coulter, J. B. Lombardini, Janice R. Sufrin, Structural and Conformational Analogues of L-Methionine as Inhibitors of the Enzymatic Synthesis of S-Adenosyl-L-methionine : III. Carbocyclic and Heterocyclic Amino Acids Molecular Pharmacology. ,vol. 10, pp. 319- 334 ,(1974)