Bioactivation by S-adenosylation, S-methylation, or N-methylation.
作者： Jerald L. Hoffman
DOI: 10.1016/S1054-3589(08)61043-1
关键词:
摘要: Publisher Summary This chapter reviews the activation of xenobiotic methionine analogs by S-adenosylation and sulfur- nitrogencontaining molecules methylation. AdoMet is second only to ATP in number different group-transfer reactions which it acts as a group donor. best known methyl donor among types that act acceptors variety species, including higher animals, are DNA, RNA, proteins lipids, amino acids, catecholamines, various other nitrogen compounds, sulfur seleniumcompounds. also during polyamine biosynthesis. It first decarboxylated form dcAdoMet, donates one aminopropyl putrescine spermidine. Spermidine then accepts from dcAdoMet spermine. The enzymatic biosynthesis interest because importance product unique nature reaction. synthesis two adenosylation utilizing ATP, being adenosylcobalamin.
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