The Development of Chemical Damage of DNA in Aqueous Solution
作者： D. Schulte-Frohlinde , E. Bothe
DOI: 10.1007/978-3-642-75148-6_34
关键词:
摘要: A summary of results obtained in our laboratory is given concerning the formation free radicals produced DNA and components following ionization or reaction with OH aqueous solution rate their conversion decay. In case laser excitation biphotonic nucleobases takes place radicalcations primarily formed are converted to neutral base by deprotonation water. The have highest spin densities at nitrogens oxygens (N- O-radicals). contrast leads carbon addition double bonds sugar H abstraction. reactions, decay these discussed special regard leading strand break (sb) formation. cells dominated endogenous thiols.
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