Bioinformatics analysis of organizational and expressional characterizations of the IFNs, IRFs and CRFBs in grass carp Ctenopharyngodon idella

作者: Zhiwei Liao , Quanyuan Wan , Jianguo Su

DOI: 10.1016/J.DCI.2016.03.020

关键词:

摘要: Interferons (IFNs) play crucial roles in the immune response of defense against viral infection and bacteria invasion. In present study, we systematically identified characterized IFNs, their regulatory factors (Interferon Regulatory Factors, IRFs) receptors (Cytokine Receptor Family B, CRFBs) grass carp (Ctenopharyngodon idella). Grass IFNs can be classified into type I IFN (IFN-I) II (IFN-II) like other teleosts. IFN-I consist two groups with (group I) or four II) cysteines mature peptide further divided three subgroups (IFN-a, -c -d), containing members: IFN1, IFN2, IFN3, IFN4 carp. IFN-II contain members, IFNγ2 similarity to mammalian IFNγ a cyprinid specific IFNγ1 (IFNγ-rel) molecule. mRNA expression analyses discovered that IFN1 were sustainably expressed many tissues, while members transiently tissues time points. response, transcriptions are primarily regulated through multiple IRFs after reovirus (GCRV) challenge. IRF family possess thirteen carp, which subfamilies (IRF-1, -3, -4 -5 subfamily), each them plays different innate adaptive immunity via various signaling pathways interact (mainly IFN-I). have bind (CRFBs) perform functions. CRFBs as six The structure characterizations analyzed using bioinformatics tools. These results might provide basic data for functional research system, deeply understand fish mechanisms virus infection.

参考文章(48)
Chang Shu, Yueyan Sun, Tianjun Xu, Molecular characterization of three IRF1 subfamily members reveals evolutionary significance of IRF11 in miiuy croaker. Developmental and Comparative Immunology. ,vol. 53, pp. 385- 391 ,(2015) , 10.1016/J.DCI.2015.07.009
Georges Lutfalla, Hugues Roest Crollius, Nicole Stange-thomann, Olivier Jaillon, Knud Mogensen, Danièle Monneron, Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: the class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. ,vol. 4, pp. 29- 29 ,(2003) , 10.1186/1471-2164-4-29
Yaping Wang, Ying Lu, Yong Zhang, Zemin Ning, Yan Li, Qiang Zhao, Hengyun Lu, Rong Huang, Xiaoqin Xia, Qi Feng, Xufang Liang, Kunyan Liu, Lei Zhang, Tingting Lu, Tao Huang, Danlin Fan, Qijun Weng, Chuanrang Zhu, Yiqi Lu, Wenjun Li, Ziruo Wen, Congcong Zhou, Qilin Tian, Xiaojun Kang, Mijuan Shi, Wanting Zhang, Songhun Jang, Fukuan Du, Shan He, Lanjie Liao, Yongming Li, Bin Gui, Huihui He, Zhen Ning, Cheng Yang, Libo He, Lifei Luo, Rui Yang, Qiong Luo, Xiaochun Liu, Shuisheng Li, Wen Huang, Ling Xiao, Haoran Lin, Bin Han, Zuoyan Zhu, The draft genome of the grass carp ( Ctenopharyngodon idellus ) provides insights into its evolution and vegetarian adaptation Nature Genetics. ,vol. 47, pp. 962- 962 ,(2015) , 10.1038/NG0815-962A
Jun Zou, Carolina Tafalla, Jonathan Truckle, Chris J. Secombes, Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates. Journal of Immunology. ,vol. 179, pp. 3859- 3871 ,(2007) , 10.4049/JIMMUNOL.179.6.3859
Dina Aggad, Martine Mazel, Pierre Boudinot, Knud Erik Mogensen, Ole Jensen Hamming, Rune Hartmann, Sergei Kotenko, Philippe Herbomel, Georges Lutfalla, Jean-Pierre Levraud, The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains. Journal of Immunology. ,vol. 183, pp. 3924- 3931 ,(2009) , 10.4049/JIMMUNOL.0901495
José M González-Navajas, Jongdae Lee, Michael David, Eyal Raz, None, Immunomodulatory functions of type I interferons Nature Reviews Immunology. ,vol. 12, pp. 125- 135 ,(2012) , 10.1038/NRI3133
Baojian Sun, Linn Greiner-Tollersrud, Ben F. Koop, Børre Robertsen, Atlantic salmon possesses two clusters of type I interferon receptor genes on different chromosomes, which allows for a larger repertoire of interferon receptors than in zebrafish and mammals Developmental and Comparative Immunology. ,vol. 47, pp. 275- 286 ,(2014) , 10.1016/J.DCI.2014.08.007
Jun Zou, Christopher J. Secombes, Teleost fish interferons and their role in immunity. Developmental and Comparative Immunology. ,vol. 35, pp. 1376- 1387 ,(2011) , 10.1016/J.DCI.2011.07.001
Daniela Casani, Elisa Randelli, Susan Costantini, Angelo M. Facchiano, Jun Zou, Sam Martin, Chris J. Secombes, Giuseppe Scapigliati, Francesco Buonocore, Molecular characterisation and structural analysis of an interferon homologue in sea bass (Dicentrarchus labrax L.). Molecular Immunology. ,vol. 46, pp. 943- 952 ,(2009) , 10.1016/J.MOLIMM.2008.09.016