Strategies and Implications for Prime-Boost Vaccination to Generate Memory CD8 T Cells

作者: Jeffrey C. Nolz , John T. Harty

DOI: 10.1007/978-1-4419-5632-3_7

关键词:

摘要: Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against variety human diseases. Indeed, experimental models have demonstrated that the overall number present at time infection correlates strongly with ability to confer host protection range different pathogens. Currently, most conceivable approach rapidly generate through use prime-boost vaccination. In addition, recent findings uncovered important principles govern both rate and magnitude cell formation. Thus, this has resulted in novel vaccination strategies could potentially be used humans protective populations cells.

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