The influence of delivery vectors on HIV vaccine efficacy.

摘要: Development of an effective HIV/AIDS vaccine remains a big challenge, largely due to the enormous HIV diversity which propels immune escape. Thus novel strategies are targeting multiple variants conserved antibody and T cell epitopic regions would incur huge fitness cost virus in event mutational Besides immunogen design, delivery modality is critical for potency efficacy, should be carefully selected order not only maximize transgene expression, but also enhance immuno-stimulatory potential activate innate adaptive systems. To date, five candidates have been evaluated efficacy protection from acquisition was achieved small proportion vaccinees RV144 study used canarypox vector delivery. Conversely, STEP (HVTN 502) where human adenovirus serotype 5 (Ad5) used, strong responses were induced vaccination more associated with increased risk than pre-existing Ad5 immunity. The possibility that immunity highly promising may alter natural course increase quite worrisome setback development. Thus, development efforts now geared toward platforms attain superior immunogenicity while concurrently limiting catastrophic effects likely arise or vector-related immuno-modulation. However, it still unclear whether poor antigens substandard immunological safer vectors has limited success vaccines. This article discusses some harnessed improved efficacy.