pH Sensitive Liposomes as Efficient Carriers for Intracellular Delivery of Oligonucleotides

摘要: Antisense oligonucleotides with base sequence complementary to a specific RNA or DNA seem provide promising new tool for the therapy of viral diseases and cancer. They offer exciting potential selectively modulating expression an individual gene (Helene Toulme, 1990). The have been used successfully in cell culture inhibit HIV genes (Agrawal et al, 1988; Goodchild Lisziewicz 1988) there is now widespread interest extending use antisense compounds vivo setting (Bayever 1993; Wahlestedt 1993). However, before therapeutic can be fullfilled, it will necessary overcome significant problems relating their poor stability ability reach intracellular target.