Is Sex a Determinant of COVID-19 Infection? Truth or Myth?

摘要: Angiotensin-converting enzyme 2 (ACE2), a specific high-affinity angiotensin II-hydrolytic enzyme, is the vector that facilitates cellular entry of SARS-CoV-1 and novel SARS-CoV-2 coronavirus. SARS-CoV-2, which crossed species barriers to infect humans, highly contagious associated with high lethality due multi-organ failure, mostly in older patients other co-morbidities. Accumulating clinical evidence demonstrates intensity infection its complications are more prominent men. It has been postulated potential functional modulation ACE2 by estrogen may explain sex difference morbidity mortality. We review here regarding role estrogenic hormones expression regulation, intent bringing forefront mechanisms differences COVID-19 outcomes, assist management COVID-19, uncover new therapeutic strategies.