Greenlandic Inuit show genetic signatures of diet and climate adaptation.

摘要: The indigenous people of Greenland, the Inuit, have lived for a long time in extreme conditions Arctic, including low annual temperatures, and with specialized diet rich protein fatty acids, particularly omega-3 polyunsaturated acids (PUFAs). A scan Inuit genomes signatures adaptation revealed signals at several loci, strongest signal located cluster acid desaturases that determine PUFA levels. selected alleles are associated multiple metabolic anthropometric phenotypes large effect sizes weight height, on height replicated Europeans. By analyzing membrane lipids, we found modulate composition, which may affect regulation growth hormones. Thus, genetic physiological adaptations to PUFAs.