Brain-derived neurotrophic factor propeptide inhibits proliferation and induces apoptosis in C6 glioma cells.

摘要: There are several forms of brain-derived neurotrophic factor (BDNF), the precursor BDNF, mature and BDNF propeptide. They exert different effects through transmembrane receptor signaling systems. Precursor is enzymatically cleaved, either by intracellular or extracellular proteases, to generate its propeptide (BDNF propeptide). The aim this study was evaluate potential molecular mechanisms that underlie inhibition glioma cell growth To achieve this, we examined expression in C6 cells. 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide assay apoptosis were used assess on We found promoted decreased in-vitro growth. also using western blot cleaved caspase3 B lymphoma 2 (Bcl2)-associated X protein abundances increased, whereas Bcl2 abundance decreased. Our data suggest may have an inhibitory effect activation pathway.