Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice.

摘要: Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers, with a rising incidence worldwide. The molecular mechanisms associated development HCC are complex and include multiple interconnected alterations mounting evidence indicating an important role microRNAs (miRNAs) in pathogenesis HCC. In humans, commonly liver cirrhosis. To study fibrosis-associated carcinogenesis, we used mouse model designed to emulate cirrhotic liver. Specifically, were interested evaluating miRNAs carcinogenesis male B6C3F1/J mice treated N-nitrosodiethylamine (DEN) or carbon tetrachloride (CCl4 ) alone combination DEN CCl4 characterized by differential tumor that increased following order: DEN