Gene therapy of solid tumors and hematopoietic neoplasms

摘要: The ultimate goal in cancer treatment is to identify and correct at the molecular level derangements that cause various human malignancies. Important scientific discoveries about mechanisms through which develops are increasing likelihood introduction of foreign genetic material into mammalian cells may be used as a primary method therapy. Genetic modification malignant nonmalignant can performed on patient (in vivo) or removed from body (ex with subsequent reinfusion patient. Delivery systems gene therapy strategies have included transduction mediated by retrovirus, adenovirus, liposomes, direct injection DNA (table 1). manipulations aimed correcting disease processes already been introduced clinical trials. There now over 100 trials involving transfer antisense treatment, according records regulatory committees worldwide. These involve both marking based use designed for activation immune system, chemoprotection hematopoietic cells, chemosensitization tumor cells. major obstacles selectivity, frequencies, stability transduction, effectiveness due complexity alterations found tumors.