Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time.

摘要: Biodegradable polymer nanoparticles are an important class of materials used in several applications for their unique characteristics. In particular, the ones stabilized by zwitterionic gaining increased interest medicine as alternative to more common based on poly(ethylene glycol) thanks superior stability and ability avoid both accelerated blood clearance allergic reactions. this work, a novel NPs has been produced, method independently control nanoparticle size, degradation time, molecular weight developed demonstrated. This possible synthesis fine-tuning amphiphilic block copolymers obtained via combination ring-opening polymerization reversible addition–fragmentation chain transfer polymerization. The final results showed that when two contain same number caprolactone units, one with longer oligoester lateral ...