Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults.

摘要: Recent data suggest excess circulating aldosterone promotes cardiometabolic decline. Weight loss may lower levels, but little longitudinal is available in normotensive adults. We aimed to determine whether, independent of changes sodium excretion, reductions serum are associated with favorable obesity-related factors overweight/obese young studied 285 adult participants (body mass index ≥ 25 and<40 kg m⁻², age 20-45 years) a clinical trial examining the effects 1-year diet and physical activity intervention or without restriction on vascular health. Body weight, aldosterone, 24-h potassium excretion were measured at baseline, 6, 12 24 months. was significant 6 (7%), (6%) months (4%; all P<0.0001). Decreases decreases C-reactive protein, leptin, insulin, homeostasis assessment insulin resistance, heart rate, tonic cardiac sympathovagal balance increases adiponectin (all P<0.05) models adjusting for baseline age, sex, race, arm, time since excretion. thigh intermuscular fat (intermuscular adipose tissue area; IMAT) subgroup (n=98) metabolic syndrome (MetS) (MetS × weight loss, P=0.04; MetS change IMAT, P=0.04). Favorable adults no risk besides an important finding, given aldosterone's emergence as factor.